| Variant amino acid | Wild type amino acid |
| A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y |
| A | 0 | 14 | 4 | 4 | 12 | 4 | 7 | 6 | 6 | 8 | 7 | 2 | 5 | 4 | 8 | 1 | 2 | 4 | 23 | 13 |
| C | 4 | 0 | 9 | 9 | 13 | 8 | 9 | 7 | 10 | 12 | 11 | 6 | 9 | 9 | 10 | 2 | 5 | 6 | 25 | 10 |
| D | 2 | 17 | 0 | 1 | 15 | 4 | 5 | 7 | 5 | 10 | 9 | 0 | 7 | 2 | 7 | 2 | 3 | 6 | 24 | 14 |
| E | 2 | 17 | 1 | 0 | 14 | 5 | 5 | 7 | 5 | 9 | 8 | 1 | 7 | 2 | 7 | 2 | 3 | 6 | 24 | 14 |
| F | 5 | 16 | 10 | 9 | 0 | 10 | 8 | 4 | 10 | 4 | 6 | 5 | 11 | 9 | 10 | 5 | 6 | 5 | 17 | 3 |
| G | 1 | 15 | 3 | 4 | 14 | 0 | 8 | 8 | 7 | 10 | 9 | 2 | 6 | 5 | 9 | 1 | 3 | 5 | 24 | 15 |
| H | 3 | 15 | 3 | 3 | 11 | 7 | 0 | 7 | 5 | 8 | 8 | 0 | 6 | 1 | 4 | 3 | 4 | 6 | 20 | 10 |
| I | 3 | 14 | 6 | 6 | 8 | 8 | 8 | 0 | 7 | 4 | 4 | 4 | 8 | 6 | 8 | 3 | 3 | 0 | 22 | 11 |
| K | 3 | 17 | 4 | 4 | 14 | 7 | 6 | 7 | 0 | 9 | 6 | 1 | 7 | 3 | 3 | 2 | 3 | 6 | 20 | 14 |
| L | 4 | 18 | 8 | 7 | 7 | 9 | 8 | 3 | 8 | 0 | 2 | 5 | 9 | 6 | 9 | 5 | 5 | 2 | 19 | 11 |
| M | 3 | 17 | 7 | 6 | 9 | 8 | 8 | 3 | 5 | 2 | 0 | 4 | 8 | 5 | 6 | 4 | 4 | 2 | 21 | 12 |
| N | 2 | 16 | 2 | 3 | 12 | 5 | 4 | 7 | 4 | 9 | 8 | 0 | 6 | 3 | 6 | 1 | 3 | 6 | 21 | 12 |
| P | 1 | 15 | 5 | 5 | 14 | 5 | 6 | 7 | 6 | 9 | 8 | 2 | 0 | 4 | 6 | 1 | 3 | 5 | 23 | 15 |
| Q | 2 | 17 | 2 | 2 | 14 | 6 | 3 | 7 | 4 | 8 | 7 | 1 | 6 | 0 | 5 | 3 | 4 | 6 | 22 | 14 |
| R | 4 | 16 | 5 | 5 | 13 | 8 | 4 | 7 | 2 | 9 | 6 | 2 | 6 | 3 | 0 | 2 | 4 | 6 | 15 | 14 |
| S | 1 | 12 | 4 | 4 | 12 | 4 | 7 | 6 | 5 | 9 | 8 | 1 | 5 | 5 | 6 | 0 | 2 | 5 | 19 | 13 |
| T | 1 | 14 | 4 | 4 | 12 | 5 | 7 | 5 | 5 | 8 | 7 | 2 | 6 | 5 | 7 | 1 | 0 | 4 | 22 | 13 |
| V | 2 | 14 | 6 | 6 | 10 | 6 | 8 | 1 | 7 | 4 | 4 | 4 | 7 | 6 | 8 | 3 | 3 | 0 | 23 | 12 |
| W | 8 | 20 | 11 | 11 | 9 | 12 | 9 | 10 | 8 | 8 | 10 | 6 | 12 | 9 | 4 | 4 | 8 | 10 | 0 | 10 |
| Y | 5 | 12 | 8 | 8 | 2 | 10 | 6 | 6 | 9 | 7 | 8 | 4 | 11 | 8 | 10 | 5 | 6 | 6 | 17 | 0 |